Section on Reproductive Endocrinology
Lynnette Nieman, Section Head
The Section on Reproductive Medicine, headed by Lynnette Nieman, published a landmark article in Endocrine Reviews on the hypothalamic pituitary adrenal axis (HPA) in pregnancy; during pregnancy, diagnosis of HPA disorders presents a challenge. The section completed a study comparing immunometric and radioimmunoassay measurement of ACTH for differential diagnosis of Cushing’s syndrome. The section continues to work on the diagnosis and management of patients with hypercortisolism, recently focusing on the diagnosis and management of ectopic ACTH-secreting tumors and their localization. The section also investigates endometrial physiology and endometriosis pathologies. It has published studies on the endometrium, describing the localization of lesions in women with endometriosis and characterizing the estrogen alpha receptor and use of raloxifene as an adjunctive treatment for endometriosis. CD10 cell-surface metalloendopeptidase is present in normal endometrium, and staining of the protein is helpful in diagnosing endometriosis.